Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

The mammalian target of rapamycin complex 1 (mTORC1) is the key signaling hub that regulates cellular protein homeostasis, growth, and proliferation in health and disease. As a prerequisite for activation of mTORC1 by hormones and mitogens, there first has to be an available pool of intracellular am...

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Bibliographic Details
Main Authors: Bernadette Carroll, Dorothea Maetzel, Oliver DK Maddocks, Gisela Otten, Matthew Ratcliff, Graham R Smith, Elaine A Dunlop, João F Passos, Owen R Davies, Rudolf Jaenisch, Andrew R Tee, Sovan Sarkar, Viktor I Korolchuk
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
mTOR
amino acids
autophagy
signal transduction
Online Access:https://elifesciences.org/articles/11058

Internet

https://elifesciences.org/articles/11058

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