Combining bulk and single-cell RNA-sequencing data to develop an NK cell-related prognostic signature for hepatocellular carcinoma based on an integrated machine learning framework

Combining bulk and single-cell RNA-sequencing data to develop an NK cell-related prognostic signature for hepatocellular carcinoma based on an integrated machine learning framework

Abstract Background The application of molecular targeting therapy and immunotherapy has notably prolonged the survival of patients with hepatocellular carcinoma (HCC). However, multidrug resistance and high molecular heterogeneity of HCC still prevent the further improvement of clinical benefits. D...

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Bibliographic Details
Main Authors: Qian Feng, Zhihao Huang, Lei Song, Le Wang, Hongcheng Lu, Linquan Wu
Format: Article
Language:English
Published: BMC 2023-08-01
Series:European Journal of Medical Research
Subjects:
Hepatocellular carcinoma
Prognosis
Immunotherapy
Single-cell sequencing
Machine learning
Online Access:https://doi.org/10.1186/s40001-023-01300-6

Internet

https://doi.org/10.1186/s40001-023-01300-6

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