Olanzapine Ameliorates Ischemic Stroke-like Pathology in Gerbils and H<sub>2</sub>O<sub>2</sub>-Induced Neurotoxicity in SH-SY5Y Cells via Inhibiting the MAPK Signaling Pathway

Olanzapine Ameliorates Ischemic Stroke-like Pathology in Gerbils and H<sub>2</sub>O<sub>2</sub>-Induced Neurotoxicity in SH-SY5Y Cells via Inhibiting the MAPK Signaling Pathway

Olanzapine (OLNZ) is used to treat psychotic disorders. To look into the neurological basis of this phenomenon, we investigated the neuroprotective effects of OLNZ in gerbils and SH-SY5Y cells. Gerbils were subjected to transient global cerebral ischemia (TGCI) by blocking both common carotid arteri...

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Bibliographic Details
Main Authors: Md Sadikul Islam, Ha-Young Shin, Yeo-Jin Yoo, Ryunhee Kim, Young-Jin Jang, Md Rashedunnabi Akanda, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn, Byung-Yong Park
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
olanzapine
transient ischemia
oxidative stress
neuroprotection
antioxidant
MAPK
Online Access:https://www.mdpi.com/2076-3921/11/9/1697

Internet

https://www.mdpi.com/2076-3921/11/9/1697

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