Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit

Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit

ABSTRACT: Objectives: In hypervirulent Klebsiella pneumoniae (hvKP), the hypermucoviscous capsule is known to be a major virulence determinant. We previously discovered that rifampicin (RFP), a bactericidal drug that binds to and inhibits the β subunit of RNA polymerase (RpoB), elicits anti-mucovis...

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Bibliographic Details
Main Authors: Mitsunori Tohda, Ken-Ichi Oinuma, Arata Sakiyama, Taishi Tsubouchi, Mamiko Niki, Hiroki Namikawa, Kenshi Yamane, Koichi Yamada, Tetsuya Watanabe, Kazuhisa Asai, Hiroshi Kakeya, Yukihiro Kaneko, Tomoya Kawaguchi
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Hypervirulent Klebsiella pneumoniae
Anti-mucoviscous
Rifampicin
RpoB
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716522003617

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http://www.sciencedirect.com/science/article/pii/S2213716522003617

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