Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases

Gastroesophageal reflux disease (GERD) is a major risk factor for Barret’s esophagus (BE) and esophageal adenocarcinoma (EA). Here, An et al. report 25 genetic loci for GERD, many of which associate with BE and EA or with other traits such as BMI.

Bibliographic Details
Main Authors: Jiyuan An, Puya Gharahkhani, Matthew H. Law, Jue-Sheng Ong, Xikun Han, Catherine M. Olsen, Rachel E. Neale, John Lai, Tom L. Vaughan, Ines Gockel, René Thieme, Anne C. Böhmer, Janusz Jankowski, Rebecca C. Fitzgerald, Johannes Schumacher, Claire Palles, BEACON, 23andMe Research Team, David C. Whiteman, Stuart MacGregor
Format: Article
Language:English
Published: Nature Portfolio 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11968-2

Internet

https://doi.org/10.1038/s41467-019-11968-2

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