Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs

Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs

The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline bond was exploited to generate a new specifi...

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Bibliographic Details
Main Authors: Fiona M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall, Sumaiya Chowdhury, Sarah E. Poplawski, Jack H. Lai, Youhua Li, Wengen Wu, Penny Farrell, Ana Julia Vieira de Ribeiro, Brenna Osborne, Denise M.T. Yu, Devanshi Seth, Khairunnessa Rahman, Paul Haber, A. Kemal Topaloglu, Chuanmin Wang, Sally Thomson, Annemarie Hennessy, John Prins, Stephen M. Twigg, Susan V. McLennan, Geoffrey W. McCaughan, William W. Bachovchin, Mark D. Gorrell
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
Fibroblast
Dipeptidyl peptidase
Protease substrates
Protease activity
Liver disease
Fibrosis
Biomarker
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546313000752

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http://www.sciencedirect.com/science/article/pii/S2211546313000752

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