Chemo-Enzymatic Synthesis of Chiral Epoxides Ethyl and Methyl (S)-3-(Oxiran-2-yl)propanoates from Renewable Levoglucosenone: An Access to Enantiopure (S)-Dairy Lactone

Chemo-Enzymatic Synthesis of Chiral Epoxides Ethyl and Methyl (S)-3-(Oxiran-2-yl)propanoates from Renewable Levoglucosenone: An Access to Enantiopure (S)-Dairy Lactone

Chiral epoxides—such as ethyl and methyl (S)-3-(oxiran-2-yl)propanoates ((S)-1a/1b)—are valuable precursors in many chemical syntheses. Until recently, these compounds were synthesized from glutamic acid in four steps (deamination, reduction, tosylation and epoxide formation) in low to moderate over...

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Bibliographic Details
Main Authors: Aurélien A. M. Peru, Amandine L. Flourat, Christian Gunawan, Warwick Raverty, Martyn Jevric, Ben W. Greatrex, Florent Allais
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
epoxide
flavor
levoglucosenone
chirality
total synthesis
Online Access:http://www.mdpi.com/1420-3049/21/8/988

Internet

http://www.mdpi.com/1420-3049/21/8/988

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