Peripheral nerve injury elicits microstructural and neurochemical changes in the striatum and substantia nigra of a DYT-TOR1A mouse model with dystonia-like movements

Peripheral nerve injury elicits microstructural and neurochemical changes in the striatum and substantia nigra of a DYT-TOR1A mouse model with dystonia-like movements

The relationship between genotype and phenotype in DYT-TOR1A dystonia as well as the associated motor circuit alterations are still insufficiently understood. DYT-TOR1A dystonia has a remarkably reduced penetrance of 20–30%, which has led to the second-hit hypothesis emphasizing an important role of...

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Bibliographic Details
Main Authors: Lisa Rauschenberger, Esther-Marie Krenig, Alea Stengl, Susanne Knorr, Tristan H. Harder, Felix Steeg, Maximilian U. Friedrich, Kathrin Grundmann-Hauser, Jens Volkmann, Chi Wang Ip
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neurobiology of Disease
Subjects:
DYT-TOR1A
Dystonia
Dopamine
Medium spiny neurons
Basal ganglia
Second-hit hypothesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000700

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http://www.sciencedirect.com/science/article/pii/S0969996123000700

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