Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes

Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes

Human Fc gamma receptor IIa (FcγRIIa) or CD32a has two major allotypes with a single amino acid difference at position 131 (histidine or arginine). Differences in FcγRIIa allotypes are known to impact immunological responses such as the clinical outcome of therapeutic monoclonal antibodies (mAbs). F...

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Bibliographic Details
Main Authors: Steffen Lippold, Karishma Mistry, Sunidhi Lenka, Kevin Whang, Peilu Liu, Sebastian Pitschi, Felix Kuhne, Dietmar Reusch, Lance Cadang, Alexander Knaupp, Saeed Izadi, Alexis Dunkle, Feng Yang, Tilman Schlothauer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
affinity chromatograghy
CD32 (FcgRII)
ADCP
deamidation
molecular dynamics
mass spectrometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260446/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260446/full

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