Functional Characterization of an In-Frame Deletion in the Basic Domain of the Retinal Transcription Factor ATOH7

Functional Characterization of an In-Frame Deletion in the Basic Domain of the Retinal Transcription Factor ATOH7

Basic helix–loop–helix (bHLH) transcription factors are evolutionarily conserved and structurally similar proteins important in development. The temporospatial expression of atonal bHLH transcription factor 7 (<i>ATOH7</i>) directs the differentiation of retinal ganglion cells and mutati...

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Bibliographic Details
Main Authors: David Atac, Lucas Mohn, Silke Feil, Kevin Maggi, Dominik Haenni, Britta Seebauer, Samuel Koller, Wolfgang Berger
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
atonal bHLH transcription factor 7 (<i>ATOH7</i>)
basic helix–loop–helix (bHLH)
cycloheximide (CHX) chase assay
protein dimerization
synergistic nuclear import
dimerization-mediated proteasomal degradation
Online Access:https://www.mdpi.com/1422-0067/23/3/1053

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https://www.mdpi.com/1422-0067/23/3/1053

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