Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment

Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment

Introduction: The development of patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offers an opportunity to study genotype-phenotype correlation of hypertrophic cardiomyopathy (HCM), one of the most common inherited cardiac diseases. However, immaturity of the iPSC-CMs...

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Bibliographic Details
Main Authors: Kai Wang, Brian J. Schriver, Roozbeh Aschar-Sobbi, Alex Y. Yi, Nicole T. Feric, Michael P. Graziano
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hypertrophic cardiomyopathy
human induced pluripotent stem cells derived cardiomyocyte
engineered cardiac tissue
disease model
mavacamten
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1227184/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2023.1227184/full

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