Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK
Presenilin-1 (PS1) is the catalytic subunit of gamma-secretase. PS1 cleaves beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm. We have previously shown that rapamycin inhibits p-mTOR to repress PS1 transcr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2020-03-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/25/7/10.2741/4856 |