Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Targeting epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKI) has been widely exploited to disrupt aberrant phosphorylation flux in cancer. However, a bottleneck of potent TKIs is the acquisition of drug resistance mutations, secondary effects, and low ability to attenuate...

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Bibliographic Details
Main Authors: Melkon Iradyan, Nina Iradyan, Philippe Hulin, Artur Hambardzumyan, Aram Gyulkhandanyan, Rodolphe Alves de Sousa, Assia Hessani, Christos Roussakis, Guillaume Bollot, Cyril Bauvais, Vehary Sakanyan
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
cancer
targeting chemotherapy
receptor tyrosine kinase
allosteric site
protein degraders
autophagy
cytoskeleton
anoikis
EGFR
Bim
Online Access:https://www.mdpi.com/2072-6694/11/8/1094

Internet

https://www.mdpi.com/2072-6694/11/8/1094

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