New coumarin derivative with potential antioxidant activity: Synthesis, DNA binding and in silico studies (Docking, MD, ADMET)

A new coumarin derivative, 7-((8-(4-benzylpiperidin-1-yl)octyl)oxy)-4-methyl-2H-chromen-2-one (C3), was synthesized by two-step alkylation reaction of 7-hydroxy-4-methyl coumarin. The structure and purity of the compound were characterized by its 1H and 13C NMR, FT-IR and LC-MS spectral data. The DN...

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Bibliographic Details
Main Authors: Serda Kecel-Gunduz, Yasemin Budama-Kilinc, Bilge Bicak, Bahar Gok, Burcu Belmen, Feray Aydogan, Cigdem Yolacan
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222007560