tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR). The UPR regulates the protein folding capacity of the endoplasmic reticulum (ER). ER stres...

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Bibliographic Details
Main Authors: Jirka Peschek, Peter Walter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
unfolded protein response
tRNA splicing
RNA processing
RNA ligase
no-go decay
mRNA quality control
Online Access:https://elifesciences.org/articles/44199

Internet

https://elifesciences.org/articles/44199

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