Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Genome-wide Association Studies (GWAS) result in millions of summary statistics (``z-scores'') for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as p...

Full description

Bibliographic Details
Main Authors: Dominic eHolland, Yunpeng eWang, Wesley K Thompson, Andrew eSchork, Chi-Hua eChen, Min-Tzu eLo, Aree eWitoelar, Thomas eWerge, Michael eO'Donovan, Ole A Andreassen, Anders M. Dale
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Genetics
Subjects:
Putamen
Schizophrenia
GWAS
effect size
SNP discovery
Gaussian mixture model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00015/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00015/full

Similar Items