Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Genome-wide Association Studies (GWAS) result in millions of summary statistics (``z-scores'') for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as p...

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Bibliographic Details
Main Authors: Dominic eHolland, Yunpeng eWang, Wesley K Thompson, Andrew eSchork, Chi-Hua eChen, Min-Tzu eLo, Aree eWitoelar, Thomas eWerge, Michael eO'Donovan, Ole A Andreassen, Anders M. Dale
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Genetics
Subjects:
Putamen
Schizophrenia
GWAS
effect size
SNP discovery
Gaussian mixture model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00015/full

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