PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway

PD-L1 Regulates Platelet Activation and Thrombosis via Caspase-3/GSDME Pathway

Platelets play a central role in hemostasis and thrombosis, regulating the occurrence and development of thrombotic diseases, including ischemic stroke. Programmed death ligand 1 (PD-L1) has recently been detected in platelet, while the function of PD-L1 in platelets remain elusive. Our data reveal...

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Bibliographic Details
Main Authors: Yulong Li, Guang Xin, Shiyi Li, Yuman Dong, Yuda Zhu, Xiuxian Yu, Chengyu Wan, Fan Li, Zeliang Wei, Yilan Wang, Kun Zhang, Qingqiu Chen, Hai Niu, Wen Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
platelet
PD-L1
stroke
aggregation
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.921414/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.921414/full

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