Blocking the PI3K/AKT Pathway Enhances Mammalian Reovirus Replication by Repressing IFN-stimulated Genes

Blocking the PI3K/AKT Pathway Enhances Mammalian Reovirus Replication by Repressing IFN-stimulated Genes

Many host cellular signaling pathways were activated and exploited by virus infection for more efficient replication. The PI3K/Akt pathway has recently attracted considerable interest due to its role in regulating virus replication. This study demonstrated for the first time that the mammalian reovi...

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Bibliographic Details
Main Authors: Jin eTian, Xiaozhan eZhang, Hongxia eWu, Chunguo eLiu, Zhijie eLi, Xiaoliang eHu, Shuo eSu, Linfa eWang, Liandong eQu
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-09-01
Series:Frontiers in Microbiology
Subjects:
Endocytosis
reovirus
PI3K/AKT
IFN-stimulated genes
enhancing viral replication
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00886/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00886/full

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