Disulfide Cross-Linked Polymeric Redox-Responsive Nanocarrier Based on Heparin, Chitosan and Lipoic Acid Improved Drug Accumulation, Increased Cytotoxicity and Selectivity to Leukemia Cells by Tumor Targeting via “Aikido” Principle

Disulfide Cross-Linked Polymeric Redox-Responsive Nanocarrier Based on Heparin, Chitosan and Lipoic Acid Improved Drug Accumulation, Increased Cytotoxicity and Selectivity to Leukemia Cells by Tumor Targeting via “Aikido” Principle

We have developed a micellar formulation of anticancer drugs based on chitosan and heparin grafted with lipoic and oleic acids that can release the cytotoxic cargo (doxorubicin) in response to external stimuli, such as increased glutathione concentration—a hallmark of cancer. Natural polysaccharides...

Full description

Bibliographic Details
Main Authors: Igor D. Zlotnikov, Alexander A. Ezhov, Natalia V. Dobryakova, Elena V. Kudryashova
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Gels
Subjects:
glutathione sensitivity
tumor targeting
polymeric micelles
doxorubicin
non-target toxicity
Online Access:https://www.mdpi.com/2310-2861/10/3/157

Internet

https://www.mdpi.com/2310-2861/10/3/157

Similar Items