Effects of the Local Bone Renin-Angiotensin System on Titanium-Particle-Induced Periprosthetic Osteolysis

Effects of the Local Bone Renin-Angiotensin System on Titanium-Particle-Induced Periprosthetic Osteolysis

Wear particles may induce osteoclast formation and osteoblast inhibition that lead to periprosthetic osteolysis (PPOL) and subsequent aseptic loosening, which is the primary reason for total joint arthroplasty failure. Local bone renin-angiotensin system (RAS) has been found to participate in the pa...

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Bibliographic Details
Main Authors: Zhiping Zhao, Changyao Wang, Yingxing Xu, Xiangyu Wang, Bin Jia, Tengbo Yu, Yingzhen Wang, Yongtao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
periprosthetic osteolysis
renin-angiotensin system
titanium particles
perindopri
RANKL and wnt/β-catenin signaling pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.684375/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.684375/full

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