Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in HumansSummary

Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in HumansSummary

Background & Aims: OATP1B3/SLCO1B3 is a human liver-specific transporter for the clearance of endogenous compounds (eg, bile acid [BA]) and xenobiotics. The functional role of OATP1B3 in humans has not been characterized, as SLCO1B3 is poorly conserved among species without mouse orthologs....

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Bibliographic Details
Main Authors: Qiong Pan, Guanyu Zhu, Ziqian Xu, Jinfei Zhu, Jiafeng Ouyang, Yao Tong, Nan Zhao, Xiaoxun Zhang, Ying Cheng, Liangjun Zhang, Ya Tan, Jianwei Li, Chengcheng Zhang, Wensheng Chen, Shi-Ying Cai, James L. Boyer, Jin Chai
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Bile Acid Transporter
Cholestasis
OATP1B3
Proinflammatory Cytokine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X23000619

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http://www.sciencedirect.com/science/article/pii/S2352345X23000619

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