Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants

Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants

Background: Oral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED and RVV immunogenicity, and evaluated the effect of...

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Bibliographic Details
Main Authors: James A Church, Sandra Rukobo, Margaret Govha, Ethan K Gough, Bernard Chasekwa, Benjamin Lee, Marya P Carmolli, Gordana Panic, Natasa Giallourou, Robert Ntozini, Kuda Mutasa, Monica M McNeal, Florence D. Majo, Naume V. Tavengwa, Jonathan R. Swann, Lawrence H Moulton, Beth D Kirkpatrick, Jean H Humphrey, Andrew J Prendergast
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:EClinicalMedicine
Subjects:
Infants
Africa
Rotavirus
Oral vaccine
Enteropathy
Environmental enteric dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537021004533

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http://www.sciencedirect.com/science/article/pii/S2589537021004533

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