Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen.

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen.

Virus host shifts are generally associated with novel adaptations to exploit the cells of the new host species optimally. Surprisingly, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has apparently required little to no significant adaptation to humans since the start of the Coronaviru...

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Bibliographic Details
Main Authors: Oscar A MacLean, Spyros Lytras, Steven Weaver, Joshua B Singer, Maciej F Boni, Philippe Lemey, Sergei L Kosakovsky Pond, David L Robertson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001115

Internet

https://doi.org/10.1371/journal.pbio.3001115

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