Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

We hypothesize that different routes of administration may lead to altered pharmacokinetics/pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to improve their therapeutic index. To evaluate this hypothesis, here we performed PK/PD evaluation for an ADC administered vi...

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Bibliographic Details
Main Authors: Hsuan-Ping Chang, Huyen Khanh Le, Dhaval K. Shah
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
intratumoral administration
subcutaneous administration
antibody-drug conjugate (ADC)
local toxicity
monomethyl auristatin E (MMAE)
pharmacokinetics/pharmacodynamics (PK/PD)
Online Access:https://www.mdpi.com/1999-4923/15/4/1132

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https://www.mdpi.com/1999-4923/15/4/1132

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