Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158

Arginase-1 is a manganese-dependent metalloenzyme that catalyzes the hydrolysis of L-arginine into L-ornithine and urea. Arginase-1 is abundantly expressed by tumor-infiltrating myeloid cells that promote tumor immunosuppression, which is relieved by inhibition of Arginase-1. We have characterized t...

Full description

Bibliographic Details
Main Authors: Yvonne Grobben, Joost C.M. Uitdehaag, Nicole Willemsen-Seegers, Werner W.A. Tabak, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Structural Biology: X
Subjects:
Cancer immunotherapy
Biochemical inhibition
Surface plasmon resonance
Thermal stability
X-ray crystallography
Online Access:http://www.sciencedirect.com/science/article/pii/S2590152419300121

Internet

http://www.sciencedirect.com/science/article/pii/S2590152419300121

Similar Items