Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes

The formation of β-amyloid (Aβ) plaques is a critical neurodegenerative change in Alzheimer disease (AD). We designed and synthesized novel boron dipyrromethane (BODIPY)-based Aβ probes (BAPs) and evaluated their utility for near-infrared fluorescence imaging of Aβ plaques in the brain. In binding e...

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Bibliographic Details
Main Authors: Hiroyuki Watanabe, Masahiro Ono, Kenji Matsumura, Masashi Yoshimura, Hiroyuki Kimura, Hideo Saji
Format: Article
Language:English
Published: SAGE Publications 2013-07-01
Series:Molecular Imaging
Online Access:https://doi.org/10.2310/7290.2013.00049