Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
Hernias involve protrusion of an organ or tissue through its surrounding cavity. Here the authors carry out GWAS for five types of hernia and find 81 variants, most of which are associated with inguinal hernia; downstream analysis suggests an important role for connective tissue morphology.
Bibliographic Details
| Main Authors: |
João Fadista,
Line Skotte,
Juha Karjalainen,
Erik Abner,
Erik Sørensen,
Henrik Ullum,
Thomas Werge,
iPSYCH Group,
Tõnu Esko,
Lili Milani,
Aarno Palotie,
Mark Daly,
FinnGen Consortium,
Mads Melbye,
Bjarke Feenstra,
Frank Geller |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-30921-4
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