Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
Hernias involve protrusion of an organ or tissue through its surrounding cavity. Here the authors carry out GWAS for five types of hernia and find 81 variants, most of which are associated with inguinal hernia; downstream analysis suggests an important role for connective tissue morphology.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30921-4 |
| _version_ | 1818467972430168064 |
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| author | João Fadista Line Skotte Juha Karjalainen Erik Abner Erik Sørensen Henrik Ullum Thomas Werge iPSYCH Group Tõnu Esko Lili Milani Aarno Palotie Mark Daly FinnGen Consortium Mads Melbye Bjarke Feenstra Frank Geller |
| author_facet | João Fadista Line Skotte Juha Karjalainen Erik Abner Erik Sørensen Henrik Ullum Thomas Werge iPSYCH Group Tõnu Esko Lili Milani Aarno Palotie Mark Daly FinnGen Consortium Mads Melbye Bjarke Feenstra Frank Geller |
| author_sort | João Fadista |
| collection | DOAJ |
| description | Hernias involve protrusion of an organ or tissue through its surrounding cavity. Here the authors carry out GWAS for five types of hernia and find 81 variants, most of which are associated with inguinal hernia; downstream analysis suggests an important role for connective tissue morphology. |
| first_indexed | 2024-04-13T21:07:32Z |
| format | Article |
| id | doaj.art-69e2a81c3aa34165a7f077dd79ecf16c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T21:07:32Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-69e2a81c3aa34165a7f077dd79ecf16c2022-12-22T02:29:55ZengNature PortfolioNature Communications2041-17232022-06-0113111110.1038/s41467-022-30921-4Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated lociJoão Fadista0Line Skotte1Juha Karjalainen2Erik Abner3Erik Sørensen4Henrik Ullum5Thomas Werge6iPSYCH GroupTõnu Esko7Lili Milani8Aarno Palotie9Mark Daly10FinnGen ConsortiumMads Melbye11Bjarke Feenstra12Frank Geller13Department of Epidemiology Research, Statens Serum InstitutDepartment of Epidemiology Research, Statens Serum InstitutInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of HelsinkiEstonian Genome Center, Institute of Genomics, University of TartuDepartment of Clinical Immunology, Copenhagen University Hospital, RigshospitaletDepartment of Clinical Immunology, Copenhagen University Hospital, RigshospitaletiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric ResearchEstonian Genome Center, Institute of Genomics, University of TartuEstonian Genome Center, Institute of Genomics, University of TartuInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of HelsinkiInstitute for Molecular Medicine Finland, FIMM, HiLIFE, University of HelsinkiDepartment of Clinical Medicine, University of CopenhagenDepartment of Epidemiology Research, Statens Serum InstitutDepartment of Epidemiology Research, Statens Serum InstitutHernias involve protrusion of an organ or tissue through its surrounding cavity. Here the authors carry out GWAS for five types of hernia and find 81 variants, most of which are associated with inguinal hernia; downstream analysis suggests an important role for connective tissue morphology.https://doi.org/10.1038/s41467-022-30921-4 |
| spellingShingle | João Fadista Line Skotte Juha Karjalainen Erik Abner Erik Sørensen Henrik Ullum Thomas Werge iPSYCH Group Tõnu Esko Lili Milani Aarno Palotie Mark Daly FinnGen Consortium Mads Melbye Bjarke Feenstra Frank Geller Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci Nature Communications |
| title | Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci |
| title_full | Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci |
| title_fullStr | Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci |
| title_full_unstemmed | Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci |
| title_short | Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci |
| title_sort | comprehensive genome wide association study of different forms of hernia identifies more than 80 associated loci |
| url | https://doi.org/10.1038/s41467-022-30921-4 |
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