Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Proteomic and Single-Cell Transcriptomic Dissection of Human Plasmacytoid Dendritic Cell Response to Influenza Virus

Plasmacytoid dendritic cells [pDCs] represent a rare innate immune subset uniquely endowed with the capacity to produce substantial amounts of type-I interferons. This function of pDCs is critical for effective antiviral defenses and has been implicated in autoimmunity. While IFN-I and select cytoki...

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Bibliographic Details
Main Authors: Mustafa H. Ghanem, Andrew J. Shih, Houman Khalili, Emily G. Werth, Jayanta K. Chakrabarty, Lewis M. Brown, Kim R. Simpfendorfer, Peter K. Gregersen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
influenza virus
plasmacyotid DCs
interferon
secretome and transcriptome analysis
single cell RNA seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.814627/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.814627/full

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