Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes

Infantile (fetal and neonatal) megakaryocytes (Mks) have a distinct phenotype consisting of hyperproliferation, limited morphogenesis, and low platelet production capacity. These properties contribute to clinical problems that include thrombocytopenia in neonates, delayed platelet engraftment in rec...

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Bibliographic Details
Main Authors: Kamaleldin E. Elagib, Ashton Brock, Cara M. Clementelli, Goar Mosoyan, Lorrie L. Delehanty, Ranjit K. Sahu, Alexandra Pacheco-Benichou, Corinne Fruit, Thierry Besson, Stephan W. Morris, Koji Eto, Chintan Jobaliya, Deborah L. French, Paul Gadue, Sandeep Singh, Xinrui Shi, Fujun Qin, Robert Cornelison, Hui Li, Camelia Iancu-Rubin, Adam N. Goldfarb
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-10-01
Series:The Journal of Clinical Investigation
Subjects:
Development
Hematology
Online Access:https://doi.org/10.1172/JCI154839

Internet

https://doi.org/10.1172/JCI154839

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