MicroRNA-34c Inhibits Osteogenic Differentiation and Valvular Interstitial Cell Calcification via STC1-Mediated JNK Pathway in Calcific Aortic Valve Disease

MicroRNA-34c Inhibits Osteogenic Differentiation and Valvular Interstitial Cell Calcification via STC1-Mediated JNK Pathway in Calcific Aortic Valve Disease

Calcific aortic valve disease (CAVD), a common heart valve disease, is increasingly prevalent worldwide and causes high morbidity and mortality. Here, we aimed to investigate a possible role for miR-34c in the development of osteogenic differentiation during CAVD and to find out the underlying mecha...

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Bibliographic Details
Main Authors: Lieming Yang, Xinyuan Zhu, Yingying Ni, Dawei Wu, Yikui Tian, Zhi Chen, Mingbiao Li, Hao Zhang, Degang Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
MicroRNA-34c
stanniocalcin 1
c-Jun N-terminal kinase (JNK)
osteogenic differentiation
calcified aortic valve
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00829/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00829/full

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