Synthesis, Antibacterial and Antiribosomal Activity of the 3<i>C</i>-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-<i>O</i>-Ribofuranosyl Apramycins)

Synthesis, Antibacterial and Antiribosomal Activity of the 3<i>C</i>-Aminoalkyl Modification in the Ribofuranosyl Ring of Apralogs (5-<i>O</i>-Ribofuranosyl Apramycins)

The synthesis and antiribosomal and antibacterial activity of both anomers of a novel apralog, 5-<i>O</i>-(5-amino-3-<i>C</i>-dimethylaminopropyl-D-ribofuranosyl)apramycin, are reported. Both anomers show excellent activity for the inhibition of bacterial ribosomes and that o...

Full description

Bibliographic Details
Main Authors: Dmitrijs Lubriks, Klara Haldimann, Sven N. Hobbie, Andrea Vasella, Edgars Suna, David Crich
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antibiotics
Subjects:
aminoglycoside modifying enzymes
ribosomal methyltransferases
antibacterials
antiribosomal activity
aminoglycoside antibiotics
Online Access:https://www.mdpi.com/2079-6382/12/1/25

Internet

https://www.mdpi.com/2079-6382/12/1/25

Similar Items