Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ

Functional impact and molecular binding modes of drugs that target the PI3K isoform p110δ

Abstract Targeting the PI3K isoform p110δ against B cell malignancies is at the mainstay of PI3K inhibitor (PI3Ki) development. Therefore, we generated isogenic cell lines, which express wild type or mutant p110δ, for assessing the potency, isoform-selectivity and molecular interactions of various P...

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Main Authors: Floyd Hassenrück, Maria Farina-Morillas, Lars Neumann, Francesco Landini, Stuart James Blakemore, Mina Rabipour, Juan Raul Alvarez-Idaboy, Christian P. Pallasch, Michael Hallek, Rocio Rebollido-Rios, Günter Krause
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04921-z

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https://doi.org/10.1038/s42003-023-04921-z

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