MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G<sub>αi</sub>, G<sub>αq</sub>, Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling
The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by MRGPRX2 are rudimentarily understood, especially in cutaneous MCs, by which MRGPRX2 is chiefly expressed. Here, MCs purified from huma...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/11/6/953 |