Triple threat to cancer: rationale for combining oncolytic viruses, MEK inhibitors, and immune checkpoint blockade

In a recent edition of Science Translational Medicine, we identified an enhanced therapeutic activity when talimogene laherparepvec (T-VEC) was combined with MEK inhibition in murine melanoma tumor models. MEK inhibition increased viral replication independent of mutation status. Combination therapy...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Praveen K. Bommareddy, Samuel D. Rabkin, Howard L. Kaufman
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Taylor & Francis Group 2019-04-01
Sraith:OncoImmunology
Ábhair:
Rochtain ar líne:http://dx.doi.org/10.1080/2162402X.2019.1571390