Clinical Significance of Shared T Cell Epitope Analysis in Early De Novo Donor-Specific Anti-HLA Antibody Production After Kidney Transplantation and Comparison With Shared B cell Epitope Analysis

Clinical Significance of Shared T Cell Epitope Analysis in Early De Novo Donor-Specific Anti-HLA Antibody Production After Kidney Transplantation and Comparison With Shared B cell Epitope Analysis

In pre-sensitizing events, immunological memory is mainly created via indirect allorecognition where CD4+ T cells recognize foreign peptides in the context of self-HLA class II (pHLA) presented on antigen-presenting cells. This recognition makes it possible for naive CD4+ T-helper cells to different...

Full description

Bibliographic Details
Main Authors: Toshihide Tomosugi, Kenta Iwasaki, Shintaro Sakamoto, Matthias Niemann, Eric Spierings, Isao Nahara, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Asami Takeda, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Takaaki Kobayashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation
T cell epitope analysis
B cell epitope analysis
donor-specific antibody
PIRCHE-II
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.621138/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.621138/full

Similar Items