Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1...
Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Μορφή: | Άρθρο |
Γλώσσα: | English |
Έκδοση: |
Nature Portfolio
2017-11-01
|
Σειρά: | Nature Communications |
Διαθέσιμο Online: | https://doi.org/10.1038/s41467-017-01336-3 |