Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons

Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons

Preclinical models demonstrate that nearly all anesthetics cause widespread neuroapoptosis in the developing brains of infant rodents and non-human primates. Anesthesia-induced developmental apoptosis is succeeded by prolonged neuropathology in the surviving neurons and lasting cognitive impairments...

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Bibliographic Details
Main Authors: Omar Hoseá Cabrera, Nemanja Useinovic, Stefan Maksimovic, Michelle Near, Nidia Quillinan, Slobodan M. Todorovic, Vesna Jevtovic-Todorovic
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Neurobiology of Disease
Subjects:
Glutamate
hippocampus
Neonate
Neurotoxicity
Neurotransmission
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122003151

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http://www.sciencedirect.com/science/article/pii/S0969996122003151

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