Pemafibrate Prevents Rupture of Angiotensin II-Induced Abdominal Aortic Aneurysms

Pemafibrate Prevents Rupture of Angiotensin II-Induced Abdominal Aortic Aneurysms

BackgroundAbdominal aortic aneurysm (AAA) is a life-threatening disease that lacks effective preventive therapies. This study aimed to evaluate the effect of pemafibrate, a selective peroxisome proliferator-activated receptor alpha (PPARα) agonist, on AAA formation and rupture.MethodsExperimental AA...

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Bibliographic Details
Main Authors: Naofumi Amioka, Toru Miyoshi, Tomoko Yonezawa, Megumi Kondo, Satoshi Akagi, Masashi Yoshida, Yukihiro Saito, Kazufumi Nakamura, Hiroshi Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
pemafibrate
angiotensin II
abdominal aortic aneurysm
oxidative stress
catalase
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.904215/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.904215/full

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