Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model

Intravitreal injection of fibrillin 2 (Fbn2) recombinant protein for therapy of retinopathy in a retina-specific Fbn2 knock-down mouse model

Abstract Mutations in the extracellular matrix gene Fibrillin-2 (FBN2) are related to genetic macular degenerative disorders including age-related macular degeneration (AMD) and early-onset macular degeneration (EOMD). It was reported that the retinal protein expression of FBN2 was reduced in patien...

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Bibliographic Details
Main Authors: Rui Xue Zhang, Ying Wen, Da Dong Guo, Fu Ru Xu, Gui Min Wang, Xing Rong Wang, Yong Wei Shi, Jie Ding, Qian Jiang, Wen Jun Jiang, Jost B. Jonas, Hong Sheng Bi
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33886-6

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https://doi.org/10.1038/s41598-023-33886-6

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