Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS).Methods276 CIS patients with a minimum follow-up of 1...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.991596/full |
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| author | Carmen Alcalá Vicente Laura Lacruz Francisco Gascón Sara Carratalà Carlos Quintanilla-Bordás Maria T. Sanz María Carcelén-Gadea Javier Mallada Joan Carreres Laura Gabaldón Torres Jose Andres Dominguez Emmanuel Cañizares Sara Gil-Perotin Laura Cubas Raquel Gasqué Rubio Jéssica Castillo-Villalba Francisco Carlos Pérez-Miralles Bonaventura Casanova |
| author_facet | Carmen Alcalá Vicente Laura Lacruz Francisco Gascón Sara Carratalà Carlos Quintanilla-Bordás Maria T. Sanz María Carcelén-Gadea Javier Mallada Joan Carreres Laura Gabaldón Torres Jose Andres Dominguez Emmanuel Cañizares Sara Gil-Perotin Laura Cubas Raquel Gasqué Rubio Jéssica Castillo-Villalba Francisco Carlos Pérez-Miralles Bonaventura Casanova |
| author_sort | Carmen Alcalá Vicente |
| collection | DOAJ |
| description | ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS).Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected.Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); ≥ 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9–10.6) and cSC-T2L (HR 2.2, 1.0–6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8–12.9).DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS. |
| first_indexed | 2024-04-13T17:31:27Z |
| format | Article |
| id | doaj.art-6a03ba357ba243c6850fe579843e91f3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T17:31:27Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-6a03ba357ba243c6850fe579843e91f32022-12-22T02:37:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.991596991596Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosisCarmen Alcalá Vicente0Laura Lacruz1Francisco Gascón2Sara Carratalà3Carlos Quintanilla-Bordás4Maria T. Sanz5María Carcelén-Gadea6Javier Mallada7Joan Carreres8Laura Gabaldón Torres9Jose Andres Dominguez10Emmanuel Cañizares11Sara Gil-Perotin12Laura Cubas13Raquel Gasqué Rubio14Jéssica Castillo-Villalba15Francisco Carlos Pérez-Miralles16Bonaventura Casanova17Neuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeurology Service, Clinic University Hospital of València, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainDidactics of Mathematics Department, University of València, Valencia, SpainNeurology Service, General Hospital of València, Valencia, SpainNeurology Service, General Hospital of Elda, Alicante, SpainRadiology Service, Polytechnic and University Hospital La Fe, Valencia, SpainNeurology Service, San Francesc de Borja Hospital, Valencia, SpainNeurology Service, Clinic University Hospital of València, Valencia, SpainNeurology Service, La Ribera Hospital, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainNeuroimmunology Unit, Polytechnic and University Hospital La Fe, Valencia, SpainObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS).Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected.Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); ≥ 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9–10.6) and cSC-T2L (HR 2.2, 1.0–6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8–12.9).DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS.https://www.frontiersin.org/articles/10.3389/fneur.2022.991596/fullOCMBoligoclonal M bandsspinal cordsecondary progressive MSmultiple sclerosis |
| spellingShingle | Carmen Alcalá Vicente Laura Lacruz Francisco Gascón Sara Carratalà Carlos Quintanilla-Bordás Maria T. Sanz María Carcelén-Gadea Javier Mallada Joan Carreres Laura Gabaldón Torres Jose Andres Dominguez Emmanuel Cañizares Sara Gil-Perotin Laura Cubas Raquel Gasqué Rubio Jéssica Castillo-Villalba Francisco Carlos Pérez-Miralles Bonaventura Casanova Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis Frontiers in Neurology OCMB oligoclonal M bands spinal cord secondary progressive MS multiple sclerosis |
| title | Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| title_full | Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| title_fullStr | Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| title_full_unstemmed | Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| title_short | Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| title_sort | oligoclonal m bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis |
| topic | OCMB oligoclonal M bands spinal cord secondary progressive MS multiple sclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.991596/full |
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