In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia

In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia

Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important steps required to generate retroviral particles for the stable expression of mutant JAK3 constructs that induce constitutive JAK/STAT signaling....

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Bibliographic Details
Main Authors: Sofia A. Omari, Hansen J. Kosasih, Thomas Chung, Charles E. de Bock
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Heliyon
Subjects:
Bone marrow transplant
JAK3
STAT5
T-cell acute lymphoblastic leukemia
Retroviral transduction
Transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023092939

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http://www.sciencedirect.com/science/article/pii/S2405844023092939

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