Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

Altered expression of the L-arginine/nitric oxide pathway in ovarian cancer: metabolic biomarkers and biological implications

Abstract Motivation Ovarian cancer (OC) is a highly lethal gynecological malignancy. Extensive research has shown that OC cells undergo significant metabolic alterations during tumorigenesis. In this study, we aim to leverage these metabolic changes as potential biomarkers for assessing ovarian canc...

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Bibliographic Details
Main Authors: Linfeng Chen, Qiming Tang, Keying Zhang, Qianyang Huang, Yun Ding, Bo Jin, Szumam Liu, KuoYuan Hwa, C. James Chou, Yani Zhang, Sheeno Thyparambil, Weili Liao, Zhi Han, Richard Mortensen, James Schilling, Zhen Li, Robert Heaton, Lu Tian, Harvey J. Cohen, Karl G. Sylvester, Rebecca C. Arent, Xinyang Zhao, Doff B. McElhinney, Yumei Wu, Wenpei Bai, Xuefeng B. Ling
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Cancer
Subjects:
Arginase (ARG)
Nitric oxide synthase (NOS)
Dimethylarginine dimethylaminohydrolase (DDAH)
Protein arginine methyltransferases (PRMT)
Asymmetric dimethylarginine (ADMA)
Symmetric dimethylarginine (SDMA)
Online Access:https://doi.org/10.1186/s12885-023-11192-8

Internet

https://doi.org/10.1186/s12885-023-11192-8

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