Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis

Abstract In multiple sclerosis and the experimental autoimmune encephalomyelitis (EAE) model, both resident microglia and infiltrating macrophages contribute to demyelination as well as spontaneous remyelination. Nevertheless, the specific roles of microglia versus macrophages are unknown. We invest...

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Bibliographic Details
Main Authors: Alejandro Montilla, Alazne Zabala, Marco Er-Lukowiak, Björn Rissiek, Tim Magnus, Noelia Rodriguez-Iglesias, Amanda Sierra, Carlos Matute, María Domercq
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05551-3