Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis

Functional Alteration and Differential Expression of the Bitter Taste Receptor T2R38 in Human Paranasal Sinus in Patients with Chronic Rhinosinusitis

The bitter taste receptors (T2Rs) expressed in human sinonasal mucosae are known to elicit innate immune responses involving the release of nitric oxide (NO). We investigated the expression and distribution of two T2Rs, T2R14 and T2R38, in patients with chronic rhinosinusitis (CRS) and correlated th...

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Bibliographic Details
Main Authors: Kota Takemoto, Luga Santo Lomude, Sachio Takeno, Tomohiro Kawasumi, Yukako Okamoto, Takao Hamamoto, Takashi Ishino, Yuki Ando, Chie Ishikawa, Tsutomu Ueda
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
bitter taste receptor (T2R)
T2R14
T2R38
chronic rhinosinusitis (CRS)
eosinophils
ciliated cells
Online Access:https://www.mdpi.com/1422-0067/24/5/4499

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https://www.mdpi.com/1422-0067/24/5/4499

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