Inhibiting WEE1 Augments the Antitumor Efficacy of Cisplatin in Urothelial Carcinoma by Enhancing the DNA Damage Process

Inhibiting WEE1 Augments the Antitumor Efficacy of Cisplatin in Urothelial Carcinoma by Enhancing the DNA Damage Process

Urothelial carcinoma (UC) is characterized by a high incidence of <i>TP53</i> mutation, and overcoming resistance to cisplatin-based chemotherapy in UC is a major concern. Wee1 is a G2/M phase regulator that controls the DNA damage response to chemotherapy in <i>TP53</i>-muta...

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Bibliographic Details
Main Authors: Yu-Li Su, Ling-Yi Xiao, Shih-Yu Huang, Chia-Che Wu, Li-Chung Chang, Yi-Hua Chen, Hao-Lun Luo, Chun-Chieh Huang, Ting-Ting Liu, Jei-Ming Peng
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
WEE1
urothelial carcinoma
chemotherapy
DNA damage
cell cycle
<i>TP53</i> mutation
Online Access:https://www.mdpi.com/2073-4409/12/11/1471

Internet

https://www.mdpi.com/2073-4409/12/11/1471

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