Basal and one-month differed neutrophil, lymphocyte and platelet values and their ratios strongly predict the efficacy of checkpoint inhibitors immunotherapy in patients with advanced BRAF wild-type melanoma

Basal and one-month differed neutrophil, lymphocyte and platelet values and their ratios strongly predict the efficacy of checkpoint inhibitors immunotherapy in patients with advanced BRAF wild-type melanoma

Abstract Background To evaluate the capability of basal and one-month differed white blood cells (WBC), neutrophil, lymphocyte and platelet values and their ratios (neutrophils-to-lymphocytes ratio, NLR, and platelets-to-lymphocytes ratio, PLR) in predicting the response to immune checkpoint inhibit...

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Bibliographic Details
Main Authors: Michele Guida, Nicola Bartolomeo, Davide Quaresmini, Pietro Quaglino, Gabriele Madonna, Jacopo Pigozzo, Anna Maria Di Giacomo, Alessandro Marco Minisini, Marco Tucci, Francesco Spagnolo, Marcella Occelli, Laura Ridolfi, Paola Queirolo, Ivana De Risi, Monica Valente, Angela Monica Sciacovelli, Vanna Chiarion Sileni, Paolo Antonio Ascierto, Lucia Stigliano, Sabino Strippoli
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Translational Medicine
Subjects:
Neutrophil-to-lymphocyte ratio
Platelet-to-lymphocyte ratio
Metastatic melanoma
Checkpoint inhibitors
Online Access:https://doi.org/10.1186/s12967-022-03359-x

Internet

https://doi.org/10.1186/s12967-022-03359-x

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