Claudin-4: A New Molecular Target for Epithelial Cancer Therapy

Claudin-4: A New Molecular Target for Epithelial Cancer Therapy

Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflam...

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Bibliographic Details
Main Authors: Rina Fujiwara-Tani, Shiori Mori, Ruiko Ogata, Rika Sasaki, Ayaka Ikemoto, Shingo Kishi, Masuo Kondoh, Hiroki Kuniyasu
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
claudin-4
cancer
molecular target
tight junction
non-tight junction claudin
Online Access:https://www.mdpi.com/1422-0067/24/6/5494

Internet

https://www.mdpi.com/1422-0067/24/6/5494

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