Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

Cell therapy for Parkinson’s disease has experienced substantial growth in the past decades with several ongoing clinical trials. Despite increasing refinement of differentiation protocols and standardization of the transplanted neural precursors, the transcriptomic analysis of cells in the transpla...

Full description

Bibliographic Details
Main Authors: Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
spatial transcriptomics
Parkinson’s disease
deconvolution
single-cell sequencing
differentiation
transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300061X

Internet

http://www.sciencedirect.com/science/article/pii/S232905012300061X

Similar Items